Expecting Parents

A simple blood draw can tell doctors more about your pregnancy than ever before.

What is Panorama?™

Panorama is a Non-Invasive Prenatal Test (NIPT) that screens for Down syndrome and other genetic abnormalities caused by extra or missing genetic information in the baby’s DNA. Panorama specifically screens for the following conditions and syndromes:

  • Trisomy 21 (Down syndrome)
  • Trisomy 18 (Edwards syndrome)
  • Trisomy 13 (Patau syndrome)
  • Turner syndrome (Monosomy X)
  • Sex chromosome trisomies
  • Triploidy
  • 22q11.2 deletion (DiGeorge)
  • Angelman
  • Prader-Willi
  • Cri-du-chat
  • 1p36 deletion 

In addition to screening for genetic abnormalities, Panorama can also tell you the sex of the baby, if you so choose. 

Is Panorama right for me?

Age of the mother is the most common predictor of a higher risk for Down syndrome and several other chromosomal disorders.  Medical societies recommend screening for all moms-to-be who are either over 35, have had an abnormal ultrasound, have had a previous pregnancy with a genetic disorder or had a positive maternal serum screen.

The Panorama™ screening test also looks for certain conditions that carry an equal risk, regardless of the mother’s age.  Panorama may be appropriate for any mom who is looking for a safe and simple way to learn as much about her baby, without an invasive diagnostic procedure. 

You should ask your physician if she/he thinks the Panorama test is a good choice for you.

Request Panorama

How does it work?

Ask your doctor about the Panorama™ prenatal test

Get your blood drawn

Review result with your doctor in 7-10 days


Panorama™ is the only non-invasive prenatal screening test that distinguishes between fetal and maternal cell-free DNA thanks to SNP-based sequencing and Natera's proprietary Natus™ (Next-Generation Aneuploidy Test Using SNPs) algorithm.

Resources

 

Why Panorama?

The Panorama screening test is very accurate, simple and covers a broad range of common disorders.

Trisomy 21 is a condition caused by an extra copy of chromosome 21.  Typically, a baby will have 2 copies of each chromosome (one from the mom and one from the dad).  Babies with Down syndrome have three copies of the 21st chromosome. 

Children with Down syndrome will need extra medical care depending on the child’s specific health problems.  Most children with Down syndrome have intellectual disabilities that range from mild to moderate.  Early intervention has proven to be essential in enabling individuals with Down syndrome to lead healthy and productive lives.  Most people with Down syndrome live into their 60's and many live even longer. The presence of medical conditions, like heart defects, can affect the lifespan in these children and adults. Miscarriage occurs in about 30% of pregnancies with Down syndrome.   To learn more, go to Resources.

About 1 in 800 babies are born with Down syndrome.  However, the incidence increases with age.  A woman who is 38 year has a 1 in 177 chance of delivering a baby with Down syndrome.  Medical societies recommend screening for all pregnant women over the age of 35.  The Panorama test can tell you your risk.  A “low-risk” result means you have less than a 1 in 10,000 chance of having a baby with Down syndrome.

Trisomy 18, or Edwards syndrome, is caused when a baby has three copies of chromosome 18, instead of two. Unfortunately, most babies with Trisomy 18 die within the first few weeks of life and less than 10% live beyond one year. Infants with Trisomy 18 have severe intellectual disabilities and birth defects typically involving the heart, brain, and kidneys, and external abnormalities such as cleft lip/palate, small head, club feet, underdeveloped digits, and small jaw. Pregnancies diagnosed with Trisomy 18 are at high risk for miscarriage or stillbirth. Trisomy 18 occurs in approximately 1 in 3000 live births. There is nothing you can do during the pregnancy to cause or prevent Trisomy 18.

Trisomy 13, or Patau syndrome, is caused when a baby has three copies of chromosome 13, instead of two. Babies with Trisomy 13 require significant medical care because they have severe intellectual disabilities and birth defects. They may have heart defects, brain or spinal cord problems, extra fingers and/or toes, an opening in the lip (cleft lip) with or without an opening in the roof of the mouth (cleft palate), and weak muscle tone. Many babies have birth defects of other organs as well. Most babies born with this Trisomy 13 will not survive beyond the first weeks of life. Pregnancies diagnosed with trisomy 13 are at high risk for miscarriage or stillbirth. Trisomy 13 occurs in approximately 1 in 5000 livebirths. There is nothing you can do during the pregnancy to cause or prevent Trisomy 13.

Panorama can determine the gender of the baby as early as nine weeks gestation and will report it to you if you request it.  Panorama screens for the presence of a Y chromosome – indicating a boy.  The absence of a Y chromosome indicates that the baby is a girl.  Panorama can test for gender earlier and with significantly more accuracy than other methods. In published clinical trials, Panorama has been 100% accurate in fetal sex determination.

A microdeletion is a when a small piece of a chromosome is missing.  Some microdeletions are known to cause specific genetic syndromes.  Unlike Down syndrome and many other conditions, the chance of having a child with a microdeletion is the same regardless of the age of the mother.  So, a 28 year old has the same chance as a 38 year old – and a greater risk of having a child with a microdeletion than Down syndrome.  The most common microdeletion syndrome is 22q11.2 deletion syndrome, also known as 22q or DiGeorge syndrome, which occurs in 1 in 2000 live births.  Prenatal screening for microdeletions is particularly important because they can be difficult to diagnose in infants, and early childhood intervention can have a significant positive impact on the long term health of the baby.  To learn more, click here.

Typically, females have two X chromosomes, and males have one X and one Y chromosome. Sex chromosome abnormalities occur when there are extra, missing, or altered sex chromosomes present. Combined, sex chromosome abnormalities are more common than Down syndrome. They are also more common than some conditions that are often routinely screened for as part of a prenatal work up such as Cystic Fibrosis, Fragile X, and Spinal Muscular Atrophy.

Recent studies have demonstrated that early intervention can be effective in addressing physical, developmental, and emotional issues that may be associated with sex chromosome abnormalities. Children identified prenatally to have a sex chromosome abnormality have been shown to have a milder developmental course than when diagnosed postnatally. Available interventions include speech, physical therapy, early educational intervention, and hormone therapy. 

Monosomy X (45,X), also called Turner syndrome, is a chromosome condition caused by the absence of the second X chromosome in a female. Generally humans have 46 chromosomes that come in 23 pairs. Girls usually have two X chromosomes and boys have one X chromosome and one Y chromosome. Girls who have Monosomy X have one X chromosome instead of two.

In most cases, girls with Monosomy X will need extra medical care including hormone therapies at various stages of life. Parents who learn that their child will have Monosomy X prior to birth will have the opportunity to pursue a fetal echocardiogram at approximately 22-24 weeks gestation. If a congenital heart defect is detected, parents will have the chance to meet with pediatric cardiologists and learn what to expect for their child with regard to cardiac health after delivery. Parents will also have the chance to learn about Monosomy X and get in touch with national and local parent support groups prior to the birth of their child.

A high proportion of pregnancies with Monosomy X will result in a miscarriage in the first or second trimester of pregnancy. Knowing this ahead of time can help a couple emotionally prepare for a possible outcome.

Triploidy results when a pregnancy has an extra set of chromosomes for a total of 69 chromosomes instead of the usual 46.  At 10 weeks gestation, one in 1000 fetuses have this condition.  It is extremely rare for these pregnancies to reach term as they typically spontaneously miscarry early in pregnancy. Those few liveborns usually die within days of delivery. Babies with this condition can have various malformations involving the heart, brain, kidneys, as well as birth defects affecting the extremities and face. Carrying a baby with triploidy increases a mother's risk for a variety of conditions: pre-eclampsia (which can progress to life-threatening eclamptic seizures), excessive bleeding after delivery, and the possible development of a partial molar pregnancy, a type of gestational trophoblastic disease. In rare instances, molar pregnancies can progress to a type of cancer called choriocarcinoma and physicians need to know if a pregnancy was this type of triploidy so they can treat the woman appropriately. Triploidy usually occurs by chance. There is nothing you can do before or during pregnancy to cause or prevent triploidy.

 

Hear the personal 22q story of the President of the International 22q11.2 Foundation, Dr. Shelia Kambin.

 

More questions? See our FAQ

Compare Screening Options

Please select one of the options to the right and drag it next to the Panorama™ logo to get comparative information
Drag test here
Trisomy 21 (Down syndrome) >99%  
Trisomy 18 (Edwards syndrome) 96.4%  
Trisomy 13 (Patau syndrome) >99%  
Monosomy X (Turner syndrome) 92.9%  
Triploidy detection Yes  
Male >99.9%  
Female >99.9%  
Sex Chromosome - extra copy Yes  
22q 11.2 deletion syndrome / DiGeorge Syndrome 95.7%  
1p36 deletion syndrome / Angelman syndrome / Cri-du-chat syndrome / Prader-Willi syndrome 93.8->99%  
How early can the test be used? 9 weeks  
Diagnostic No  
Turnaround time 7-10 calendar days  

Compare

Down syndrome sensitivity (T21) >99%  
Edwards syndrome sensitivity (T18) 96.4%  
Patau syndrome sensitivity (T13) >99%  
Turner syndrome sensitivity (mX) 92.9%  
Triploidy detection Yes  
Male >99.9%  
Female >99.9%  
Sex Chromosome - extra copy Yes  
22q 11.2 deletion syndrome / DiGeorge Syndrome 95.7%  
1p36 deletion syndrome / Angelman syndrome / Cri-du-chat syndrome / Prader-Willi syndrome 93.8->99%  
How early can the test be used? 9 weeks  
Diagnostic No  
Turnaround time 7-10 calendar days  
Quad Screening
First Trimester Screening
Serum Integrated Screening
Integrated Screening
Sequential Screening
Harmony™
(Ariosa Diagnostics)
MaterniT21™
(Sequenom CMM)
NIFTY2
(BGI Health)
Verifi®
(Illumina)
LIFECODEXX

What if I receive a High-Risk result?

If you have a high-risk result your doctor will recommend a diagnostic test, typically CVS or amniocentesis.

  • Chorionic villus sampling (CVS) is done between 10 and 12  weeks in pregnancy. A small sample of the developing placenta is taken by passing a thin needle through the lower abdomen or using a flexible plastic tube through the vagina.
  • Amniocentesis (amnio) is usually done between 15 and 22 weeks in pregnancy. A small amount of the fluid that surrounds the baby is taken by passing a thin needle through the abdomen.
  • If you choose not to undergo invasive testing, confirmatory testing can be performed on the baby after delivery.

Both CVS and amniocentesis accurately diagnose chromosome problems by examining fetal cells under a microscope. However, both of these tests have a small risk  for miscarriage.

All screening tests may provide “high-risk” results when your baby is completely healthy (false positive) or may miss a chromosomal disorder (false negative).  Maternal serum screening tests, also known as first-trimester screen, quad screen or integrated screen, miss one out of seven affected pregnancies and identify twenty “high-risk” moms for every one mom who is actually carrying an affected baby.

Panorama is significantly more accurate.  Women who have a “low-risk” result have less than 1 in 10,000 chance of carrying an affected child and 9 out of 10 “high risk” results are accurate.  It is important to emphasize that all women with a “high risk” result should receive genetic counseling and be offered a diagnostic procedure for confirmation of these screening results.

 Sources